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Chemical Structure : PTC-596
CAS No.: 1610964-64-1
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PTC-596(Unesbulin, PTC 596, PTC596)
Catalog No.:聽URK-V617聽Only Used For Lab.
PTC-596 (Unesbulin, PTC596) is a novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM.
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Biological Activity
PTC-596 (Unesbulin, PTC596) is a novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM.
PTC-596 is a direct microtubule polymerization inhibitor.
PTC-596 reduces total BMI-1 protein levels by 87% and 61% in MOLM-13 and OCI-AML3 cells at 100 nM, induces apoptosis and reduces the levels of ubiquitylated histone H2A.
PTC-596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.
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Physicochemical Properties
M.Wt420.347
FormulaC19H13F5N6
CAS No.1610964-64-1
StorageSolide Powder
-20 掳C 3years;
4掳C 2yearsIn Solvent
-80掳C 6 Months
-20掳C 1 Months
Solubility10 mM in DMSO
Chemical Name5-fluoro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine
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References
1. Nishida Y, et al. Blood Cancer J. 2017 Feb 17;7(2):e527.
2, Eberle-Singh JA, et al. Clin Cancer Res. 2019 Jun 7. pii: clincanres.3281.2018. doi: 10.1158/1078-0432.CCR-18-3281.
3, Maeda A, et al. Oncotarget. 2018 Jun 19;9(47):28547-28560.
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URK-V617_COA
URK-V617_SDS
URK-V617_TDS
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聽inhibitor Wnt/Notch/Hedgehog Library
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